Viagra for Women? revisited

Sex sells. I suppose this is why the results of a study entitled “Sildenafil Treatment of Women with Antidepressant Associated Sexual Dysfunction” were reported with great enthusiasm around the world after they were published in the Journal of the American Medical Association (Jama). Yet the study is interesting for a number of reasons.

Sildenafil was originally sold as Viagra. Despite its success in treating men, there has been no equivalent drug for women. In the UK, there is only one licensed drug, Intrinsa, which is used in specific circumstances for female libido problems after gynaecological surgery.

The lack of a “female Viagra” highlights questions over the broader issue of “female sexual dysfunction”. While men with sexual problems frequently respond to drugs, female sexual problems tend to be more complex and far less amenable to pharmacological treatment.

Indeed, as the British Medical Journal noted in 2003, when female sexual dysfunction as a disorder was mooted at an “international consensus development conference” on the subject, 18 of the 19 authors had “financial interests or other relationships with a total of 22 drug companies”. The obvious concern was that the potential for profit was being put higher than the likely benefit to women.

The latest Jama research seems to have found a use for sildenafil in women. Or has it? The women in the trial were experiencing “sexual dysfunction” as a side effect of taking medication – in this case antidepressants.

In order to take part in the trial, the women had to be sexually active before they became depressed, but to have experienced sexual problems for just four weeks – a relatively short space of time.

So how much difference did sildenafil make? When its effect was compared to that of a placebo, there was no difference in the women’s ratings of their desire or arousal and only a small, if statistically significant, effect on orgasm. Forty-three per cent of the women on sildenafil experienced headaches, and both groups had similar scores for depression at the end of the eight-week study.

The logic of using one drug to treat another one’s side effects may sound perverse, but it is frequently applied in the world of medicine. The issue is making sure that each is properly justified.

http://jama.ama-assn.org/cgi/content/short/300/4/395
http://www.bmj.com/cgi/content/full/326/7379/45

Margaret McCartney is a GP in Glasgow.

• Viagra Improves Sexual Function In Women on Anti-Depression Drugs
• Sildenafil treatment of women with antidepressant-associated sexual dysfunction: a randomized controlled trial.
• What Malaysian women believe about Viagra: a qualitative inquiry.
• Viagra For Women, Not So Fast!
• Systematic review of randomised controlled trials of sildenafil (Viagra) in the treatment of male erectile dysfunction.