Circulating endothelial progenitor cells correlate with erectile function in patients with coronary heart disease.

Eur Heart J. 2006 Sep;27(18):2184-8. Epub 2006 Aug 22.
Comment in:

• Eur Heart J. 2007 Mar;28(5):639-40; author reply 640.

Baumh?kel M, Werner N, B?hm M, Nickenig G.

Klinik f?r Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universit?tsklinikum des Saarlandes, D-66421 Homburg/Saar, Germany. magnus@baumhaekel.de

AIMS: The aim of the study was to determine the influence of endothelial progenitor cells (EPC) on erectile dysfunction (ED). EPC play a major role in repair mechanisms of the endothelial monolayer, but the role of EPC in ED is unclear. METHODS AND RESULTS: Circulating levels of CD34(+)/KDR(+) and CD133(+) EPC were determined in 119 patients with known coronary artery disease. ED was evaluated with an ED-score generated from the KEED questionnaire. Prevalence of ED was 59.7%. In univariate analysis, age, hypertension, reduced left ventricular ejection fraction (LVEF), diabetes, and circulating levels of CD133(+) EPC, but not cardiovascular drug treatment were associated with ED. Body mass index (BMI) was positively (r = 0.319, P=0.003) and high-density lipoprotein was negatively (r=-0.246, P=0.034) correlated with ED. Adjustment for age, diabetes, hypertension, BMI, smoking, LVEF, use of statins and lower urinary tract symptoms, and prior coronary intervention revealed low levels of circulating immature CD133(+) EPC as independent risk factor for ED (95% CI -11.183 to -1.7371, P=0.008). CONCLUSION: Reduced levels of circulating CD133(+) EPC are an independent risk factor for ED. Thus, EPC may be a link between cardiovascular risk factors, endothelial dysfunction, and ED.16926179 [PubMed - indexed for MEDLINE]

• Erectile dysfunction correlates with left ventricular function and precedes cardiovascular events in cardiovascular high-risk patients.
• Coronary endothelial dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis.
• Prevalence of cardiovascular risk factors in erectile dysfunction.
• Erectile dysfunction in healthy subjects predicts reduced coronary flow velocity reserve.
• Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease.